Ginseng and its ginsenosides
Stroke, Alzheimer´s disease, Parkinson disease, major depression and multiple sclerosis. Diseases where science is still investigating treatment possibilities – Ginseng could be a solution.
It belongs to one of the oldest traditional herbal medicines, known for over 2000 years as anti-anxiety, antidepressant and cognition enhancing. The ginseng root includes more than 60 ginsenosides, e.g. Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, Rg2, and Rg3, which act as bioactive ingredients.
A recently published review by Wei-Yi Ong et al. describes the protective effects of ginsenosides on those neurological disorders. It becomes evident that ginsenosides act neuroprotective by reducing free radicals and enhancing brain functions. The authors hope to enhance the interest in more studies focused on its efficacy in treating neurological problems.
Cfm Oskar Tropitzsch GmbH provides both Panax ginseng and several of its ginsenosides.
- Protective effects of ginseng on neurological disorders. Ong WY, Farooqui T, Koh HL, Farooqui AA, Ling EA. Front Aging Neurosci. 2015 Jul 16;7:129. doi: 10.3389/fnagi.2015.00129. eCollection 2015. Review.
- Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Ye R1, Kong X, Yang Q, Zhang Y, Han J, Li P, Xiong L, Zhao G. Neurotherapeutics. 2011 Jul;8(3):515-25. doi: 10.1007/s13311-011-0051-3.
- Effects of Panax notoginseng saponin on α, β, and γ secretase involved in Aβ deposition in SAMP8 mice. Huang J1, Wu D, Wang J, Li F, Lu L, Gao Y, Zhong Z. Neuroreport. 2014 Jan 22;25(2):89-93. doi: 10.1097/WNR.0000000000000048.
- Panax ginseng is neuroprotective in a novel progressive model of Parkinson’s disease. Van Kampen J. M., Baranowski D. B., Shaw C. A., Kay D. G. (2014). Exp. Gerontol. 50, 95–105. 10.1016/j.exger.2013.11.012
- Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice. Zhu D., Liu M., Yang Y., Ma L., Jiang Y., Zhou L., et al. . (2014). J. Neurosci. Res. 92, 1217–1226. 10.1002/jnr.23397
- 20 (S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Xu C., Teng J., Chen W., Ge Q., Yang Z., Yu C., et al. . (2010). Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 1402–1411. 10.1016/j.pnpbp.2010.07.010