Novel application for Rapamycin / Siroliums
Rapamycin is used since many years in different pharmaceutical applications. Some examples are the prevention of transplant rejection as well as the coating of coronary stents. Now Sirolimus also shows promise in treating tuberous sclerosis complex, in special facial angiofibromas. An easy to compound and to apply rapamycin cream shows dramatic improvement of this tuberous […]
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Fisetin and Hesperetin
The flavonoids fisetin and hesperetin have several pharmaceutical effects, like antioxidative and anti-inflammatory. Fisetin is also known for being neuroprotective and a promising agent for Alzheimer-treatment. A recent publication is concentrating on the anti-leukemia property of these two phytochemicals. Adan A. et al. have investigated the antiproliferative and apoptotic actions on human HL60 acute promyelocytic […]
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RICT 2015 – Avignon
July 1st – 3rd, 2015 Avignon, France Université d`Avignon et des Payes de Vaucluse Cfm Oskar Tropitzsch is going to exhibit at the International Conference on Medicinal Chemistry. Visit us at our booth #31 —- The French Medicinal Chemistry Society (Société de Chimie Thérapeutique – SCT) is pleased to invite you to Avignon, for the […]
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3,3`,5,5` Tetramethylbenzidin (CAS-No.: 54827-17-7)
If you are using TMB for the production of your i.e. test-kits, don`t hesitate to ask us for our offer. TMB is a substrate for horseradish peroxidase. Tetramethylbenzidin develops a soluble blue reaction product that most of the time can be read at 370 or 655 nm. Recommended for ELISA (microwell) procedures. Go to product […]
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Ochratoxin A – 50th birthday
Ochratoxin A was discovered 1969 in South Africa, as a toxic metabolite of Aspergillus ochraceus from corn meal intentionally inoculated with said microfungus (Van der Merwe, 1965). Prompt after this first discovery, naturally occuring Ochratoxin A was isolated from a commercial corn sample in the USA (Shotwell et al., 1969). Also in 1969 (van Walbeek […]
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Englerin A
Screening of plant extracts in search of new agents to treat cancer resulted in the discovery of Englerin A. A natural product, isolated from Phyllanthus engleri, shows potent selective cytotoxicity against renal cancer cells. But very little was known about its mechanism of action. Recently it was recovered that sesquiterpene (-)-englerin A was selectively killing renal […]
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Ursolic acid
Ursolic acid is present in many plants but also fruits from daily life, like apples. It is known to be pro-apoptotic [1], suppresses tumor-invasion and has an anti-metastatic potential [2]. Besides its potential in being interesting for cancer research, it has an effect on muscle atrophy. Xu H. et al [3] found that Ursolic acid […]
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ADCs – Network Services
Cfm Oskar Tropitzsch does not sell payloads for antibody-drug conjugates (ADCs) only but offers a wide range of services around this topic. We are pleased to help you get in contact with the specialists you need. Analytical support Conjugation (non GMP/cGMP) Linker (Peptide/Novel approaches) Pre-clinical development for anti-cancer and anti-inflammatory drugs Toxin development Tumor models Contact […]
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Anisomycin
Cfm Oskar Tropitzsch GmbH is your premium research grade supplier for Anisomycin from Streptomyces griseolus. Following our philosphy we offer quantities from mg to kg. Description: Anisomycin is a pyrrolidine antibiotic that inhibits protein and DNA synthesis. Anisomycin acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Actinomycin is described to induce apoptosis in avariety of cells including promyelocytic leukemia cells, Jurkat […]
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BIO 2015 – The Global Event for Biotechnology
June15th-18th, 2015 Pennsylvania Convention Center Philadelphia PA, USA Cfm Oskar Tropitzsch GmbH will participate at the international Bio Convention 2015 in Philadelphia PA, USA. We would be glad to meet you. Meet us at our booth 913-03 About Bio: Thousands of companies from around the world and all industry segments will be at BIO, ready to […]
Read moreProducts for food safety Mycotoxin standards and standard solutions
Cfm Oskar Tropitzsch GmbH is known to supply the full range of economically significant and regulated aflatoxin standards. The most important ones are i.e.: Aflatoxin B1, B2, G1, G2, M1, M2. These standards are available in crystalline form as well as ready to use standard solutions. Most countries are controlling the presence and the content […]
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Pyrrolizidine alkaloids
Pyrrolizidine alkaloids are secondary metabolites, produced by several plant species as protection against insect herbivores. They are common food contaminants in herbs, tea, salad, leafy vegetables and honey. Feed can be contaminated so that the plant products find their way in the food chain indirectly also over meat, milk and eggs. Pyrrolizidine alkaloids have adverse […]
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