Fisetin

Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.Noh EM, Park YJ, Kim JM, Kim MS, Kim HR, Song HK, Hong OY, So HS, Yang SH, Kim JS, Park SH, Youn HJ, You YO, Choi KB, Kwon KB, Lee YR.Eur J Pharmacol. 2015 Jun 20;764:79-86. doi: 10.1016/j.ejphar.2015.06.038. [Epub ahead of print]***The pleiotropic effects of fi setin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks.Adan A, Baran Y. Tumour Biol. 2015 Jun 17. [E pub ahead of print]***Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells.Ash D, Subramanian M, Surolia A, Shaha C. Am J Cancer Res. 2015 Jan 15;5(2 ):481-97. eCollection 2015.***Fisetin Suppresses Lipid Accumulation in Mouse Adipocytic 3T3-L1 Cells by Repressing GLUT4-Mediated Glucose Uptake through Inhibition of mTOR-C/EBPa Signaling.Watanabe M, Hisatake M, Fujimori K. J Agric Food Chem. 2015 May 27;63(20):4979-87. doi: 10.1021/acs.jafc.5b00821. Epub 2015 May 18.***Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhib iting HSF1 activity through blocking its binding to the hsp70 promoter.Kim JA, Lee S, Kim DE, Kim M, Kwon BM, Han DC. Carcinogenesis. 2015 Jun;36(6):696-706. doi: 10.1093/carcin/bgv045. Epub 2015 Apr 3.***Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spi