Amarogentin

Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC ? 2-PKC and MAPK pathways.Yen TL, Lu WJ, Lien LM, Thomas PA, Lee TY, Chiu HC, Sheu JR, Lin KH.Biomed Res Int. 2014;201 4:728019. doi: 10.1155/2014/728019. Epub 2014 Apr 29.***The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition b y amarogentin, a secoiridoid glycoside from Swertia chirayita.Shukla S, Bafna K, Sundar D, Thorat SS.PLoS One. 2014 Mar 6;9(6):e90637. doi: 10.1371/journal.pone.0090637. eCollection 2014.***Preven tion of liver carcinogenesis by amarogentin through modulation of G1/S cell cycle check point and induction of apoptosis.Pal D, Sur S, Mandal S, Das A, Roy A, Das S, Panda CK.Carcinogenesis. 2012 De c;33(12):2424-31. doi: 10.1093/carcin/bgs276. Epub 2012 Sep 4.***The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.Behrens M , Brockhoff A, Batram C, Kuhn C, Appendino G, Meyerhof W.J Agric Food Chem. 2009 Nov 11;57(21):9860-6. doi: 10.1021/jf9014334.