N N O O O OH HN HCl

Belotecan HCl

Artikelnummer:

5600160

CAS Nr.:

213819-48-8

Formel:

C25H28ClN3O4

Synonyme:

Camtobell hydrochloride; CKD-602

Molekulargewicht:

469,97 g/mol

Belotecan Hydrochloride is the hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication. Potential mode of action/Key words: Targeting DNA, Topoisomerase inhibitor, Induces Apoptosis

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Belotecan HCl

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Cfm Oskar Tropitzsch GmbH ist bekannt dafür, ausgefallene Forschungsreagenzien zu liefern – in diesem Falle Cytoxoxins für Antikörper. Bei diesen „Warheads“ handelt es sich um hoch toxische Substanzen, wie z.B. ...

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