Casticin

Casticin inhibits COX-2 and iNOS expression via suppression of NF-?B and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages.Liou CJ, Len WB, Wu SJ, Lin CF, Wu XL, Huang WC.J Ethnophar macol. 2014 Dec 2;158 Pt A:310-6. doi: 10.1016/j.jep.2014.10.046. Epub 2014 Oct 31.***Molecular mechanisms of casticin action: an update on its antitumor functions.Rasul A, Zhao BJ, Liu J, Liu B, S un JX, Li J, Li XM.Asian Pac J Cancer Prev. 2014;15(21):9049-58.***Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptos is of colon cancer cells.Qu L, Liu FX, Cao XC, Xiao Q, Yang X, Ren KQ.Exp Ther Med. 2014 Nov;8(5):1494-1500. Epub 2014 Aug 26.***Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell line.He G, Cao X, He M, Sheng X, Wu Y, Ai X.Oncol Lett. 2014 Jun;7(6):2023-2028. Epub 2014 Mar 14.***Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkh ead box protein M1.Liu LP, Cao XC, Liu F, Quan MF, Sheng XF, Ren KQ.Oncol Lett. 2014 May;7(5):1711-1717. Epub 2014 Feb 25.***Casticin inhibits epithelial-mesenchymal transition of liver cancer ste m cells of the SMMC-7721 cell line through downregulating Twist.He M, Cao XC, He GC, Sheng XF, Ai XH, Wu YH.Oncol Lett. 2014 May;7(5):1625-1631. Epub 2014 Feb 21.