Conantokin G



CAS Nr.:


Chemische Beschreibung:

Sequence: H-Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2


2264,20 g/mol

Conantokin G has been isolated from the venom of the cone Conus geographus. This toxin selectively inhibits NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Conantokin G induces sleep-like symptoms in young mice and hyperactivity in older mice(SERT). In this moment this compound is under phase II clinical trials under the name CGX-1007 by Cognetix Inc. It has been shown to be an effective antiepileptic agent in several animal models of seizur.

Informieren Sie sich über
Conantokin G