Eupatorin

Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway.Estévez S, Marrero MT, Quintana J, Estévez F.PLoS One. 2014 N ov 12;9(11):e112536. doi: 10.1371/journal.pone.0112536. eCollection 2014.***Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosip hon stamineus leaves.Dolecková I, Rárová L, Grúz J, Vondrusová M, Strnad M, Kryštof V.Fitoterapia. 2012 Sep;83(6):1000-7. doi: 10.1016/j.fitote.2012.06.002. Epub 2012 Jun 12.***Flavonoids eupatori n and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.Laavola M, Nieminen R, Yam MF, Sadikun A, Asmawi MZ, Basir R, Welling J, Vapaatalo H , Korhonen R, Moilanen E.Planta Med. 2012 May;78(8):779-86. doi: 10.1055/s-0031-1298458. Epub 2012 Apr 19.***The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apo ptosis.Salmela AL, Pouwels J, Kukkonen-Macchi A, Waris S, Toivonen P, Jaakkola K, Mäki-Jouppila J, Kallio L, Kallio MJ.Exp Cell Res. 2012 Mar 10;318(5):578-92. doi: 10.1016/j.yexcr.2011.12.014. Epub 2011 Dec 29.***The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.Androutsopoulos VP, Li N, Arroo RR.J Nat Prod. 2009 Aug;72(8):1390-4. doi: 10.1021/np9 00051s.***Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 hu