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Partners of us have recently isolated a compound related to Callystatin A. A Powerpoint file where the structural differences can be seen is available between the molecule HL-100-AL1-R01 (H-3137) and Callystatin A. You will also find there the bibliographic references where Callystatin A was described as a antitumoral polyketide with extreme potency against the human epidermoid carcinoma KB cells (IC50=10 pg/ml) and the mouse lymphocytic leukemia Ll210 cells (IC50=20 pg/ml), and where several parts of the molecule (in common with our new structure) are described as crucial. This compound has not shown activity at 20µg/ml against A549, HCT-116, PSN1 y T98G cell lines, but Callystatin was described to be very selective. We have some stock, and would be able to provide (sell) material for the tumoral cell panel assays to check whether it results pM/active in any of the cell lines you are considering. Potential mode of action/Key words: Potential Antitumoral
Cfm Oskar Tropitzsch GmbH ist bekannt dafür, ausgefallene Forschungsreagenzien zu liefern – in diesem Falle Cytoxoxins für Antikörper. Bei diesen „Warheads“ handelt es sich um hoch toxische Substanzen, wie z.B. ...