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Artikelnummer:
5501149
CAS Nr.:
87081-36-5
Formel:
C32H46O6
Chemische Beschreibung:
19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Synonyme:
Jildamycin
Molekulargewicht:
526,70 g/mol
Leptomycins are antifugal antibiotics with unique unsaturated, branched-cain fatty acid structures. Both are considered to be spectific inhibitors of nuclear export protein. The physiochemical and biological properties of Leptomycins A and B are very similar. Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES), and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5. Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.
Allgemein ist Fermentation (von lat. fermentare = gären) definiert als Stoffumwandlung unter aeroben oder anaeroben Bedingungen durch Einwirkung von Mikroorganismen."Mikroorganismus" ist eine Sammelbezeichnung für gewöhnlich mikroskopisch kleine, überwiegend einzellige Organismen ...