Leptomycin A

Leptomycins are antifugal antibiotics with unique unsaturated, branched-cain fatty acid structures. Both are considered to be spectific inhibitors of nuclear export protein. The physiochemical and biological properties of Leptomycins A and B are very similar. Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES), and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5. Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.similar. Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES), and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been shown that Leptomycin A has similar effects and can induce, for example, nuclear a