O O O OH O OH

Leptomycin A

Artikelnummer:

5501149

CAS No.:

87081-36-5

Formel:

C32H46O6

Chemische Beschreibung:

19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Synonyme:

Jildamycin

Molekulargewicht:

526,70 g/mol

Leptomycins are antifugal antibiotics with unique unsaturated, branched-cain fatty acid structures. Both are considered to be spectific inhibitors of nuclear export protein. The physiochemical and biological properties of Leptomycins A and B are very similar. Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES), and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5. Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.

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Leptomycin A

Fermentationsprodukte

Allgemein ist Fermentation (von lat. fermentare = gären) definiert als Stoffumwandlung unter aeroben oder anaeroben Bedingungen durch Einwirkung von Mikroorganismen."Mikroorganismus" ist eine Sammelbezeichnung für gewöhnlich mikroskopisch kleine, überwiegend einzellige Organismen ...

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