PNU-159682

Artikelnummer:

5600024

CAS Nr.:

202350-68-3

Formel:

C32H35NO13

Chemische Beschreibung:

(7S,9S)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-7-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,7]tridecan-4-yl]oxy]-8,10-dihydro-7H-tetracene-5,12-dione

Molekulargewicht:

641,62 g/mol

PNU-159682 is a bioactive metabolite of Nemorubicin. It is approximately 3,000-fold more toxic than doxorubicin. The antitumor anthracycline nemorubicin is converted by human liver microsomes to a major metabolite, PNU-159682 (PNU). The mechanism of action of nemorubicin appears different from other anthracyclines and until now is the object of studies. In fact PNU is deemed to play a dominant, but still unclear, role in the in vivo antitumor activity of nemorubicin. PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. Potential mode of action/Key words: Targeting DNA, DNA alkylating, Cytotoxic, Antitumoral

Informieren Sie sich über
PNU-159682

ADCs

Cfm Oskar Tropitzsch GmbH ist bekannt dafür, ausgefallene Forschungsreagenzien zu liefern – in diesem Falle Cytoxoxins für Antikörper. Bei diesen „Warheads“ handelt es sich um hoch toxische Substanzen, wie z.B. ...

Mehr erfahren