Astragalus membranaceus and its Astragalosides
Of two recently published studies, one is focusing on the effect of Astragalus membranaceus on colorectal cancer. The antitumor effect was assessed on subcutaneous tumors of human colorectal cancer cell line grafted into nude mice. The profiling of the microarray expression of the tumors showed its potential as a therapeutic drug. Another publication discusses the beneficial effect of Astragaloside on Alzheimer’s Disease condition using cultured primary cortical cells under β-amyloid exposure. The authors suggest that the cortical PI3K/AKT and MAPK (or ERK) pathways are appealing therapeutic targets in treating Alzheimer´s Disease and Astragaloside may have a positive impact via modulation of both PI3K/AKT and ERK pathways.
Astragalus m. as well as its phytochemicals are getting more and more in the focus of research. Cfm Oskar Tropitzsch GmbH can provide you with both, the plant material and its Astragalosides.
An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract. Tseng A, Yang CH, Chen CH, Chen CH, Hsu SL, Lee MH, Lee HC, Su LJ. Oncol Rep. 2016 Feb;35(2):659-68. doi: 10.3892/or.2015.4441. Epub 2015 Nov 23.
Beneficial Effect of Astragaloside on Alzheimer’s Disease Condition Using Cultured Primary Cortical Cells Under β-amyloid Exposure. Chang CP, Liu YF, Lin HJ, Hsu CC, Cheng BC, Liu WP, Lin MT, Hsu SF, Chang LS, Lin KC. Mol Neurobiol. 2015 Dec 22. [Epub ahead of print]