Cytisin

Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of ?FosB in mice.Sajja RK, Rahman S.Alcohol. 2013 Jun;47(4):299-307. doi: 10.1016/j.alcohol.2013.0 2.003. Epub 2013 Apr 17.***Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors.Li YJ, Yang Q, Zhang K, Guo YY, Li XB, Yang L, Zhao MG , Wu YM.Neurotoxicology. 2013 Jan;34:219-25. doi: 10.1016/j.neuro.2012.09.009. Epub 2012 Sep 26.***Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant -like properties in male C57BL/6J mice.Mineur YS, Somenzi O, Picciotto MR.Neuropharmacology. 2007 Apr;52(5):1256-62. Epub 2007 Jan 20.***C3-halogenation of cytisine generates potent and efficaciou s nicotinic receptor agonists.Abin-Carriquiry JA, Voutilainen MH, Barik J, Cassels BK, Iturriaga-Vásquez P, Bermudez I, Durand C, Dajas F, Wonnacott S.Eur J Pharmacol. 2006 Apr 24;536(1-2):1-11. Epu b 2006 Mar 6.