Ursolic acid

Ursolic acid is present in many plants but also fruits from daily life, like apples. It is known to be pro-apoptotic [1], suppresses tumor-invasion and has an anti-metastatic potential [2]. Besides its potential in being interesting for cancer research, it has an effect on muscle atrophy. Xu H. et al [3] found that Ursolic acid ameliorated the symptoms of experimental autoimmune myasthenia gravis either over Fas-mediated apoptosis or up-regulation of Treg cells.

Cfm Oskar Tropitzsch offers Ursolic acid and other phytochemicals, like Apigenin, Baicalin, Betulin, Betulinic acid, Puerarin, Baicalein, (-)-Epicatechin and Epigallocatechin gallate as reference standards and in bulk quantities.

  1. Hsu YL, Kuo PL, Lin CC. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci. 2004 Sep 24;75(19):2303-16.
  2. Cha HJ, Bae SK, Lee HY, Lee OH, Sato H, Seiki M, Park BC, Kim KW. Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cancer Res. 1996 May 15;56(10):2281-4
  3. Xu H, Zhang M, Li XL, Li H, Yue LT, Zhang XX, Wang CC, Wang S, Duan RS. Low and high doses of ursolic acid ameliorate experimental autoimmune myasthenia gravis through different pathways. J Neuroimmunol. 2015 Apr 15;281:61-7. doi: 10.1016/j.jneuroim.2015.02.010. Epub 2015 Mar 3.

Product details:

Code: 7500967
CAS-No.: 77-52-1
Formula: C30H48O3
Molecular weight: 456,70 g/mole

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